On 2/21/2019, I got this notice for media coverage;
"Dear Hiroshi, Your article is now featured online on Medicine Innovates Series (https://medicineinnovates.com/ ). It was also shared with the scientific and medical community. ...I wish you best of luck in your future studies."
Here is the link to the article, with some excerpts.
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Title: "Making mice Alzheimer’s without manipulating amyloid metabolism; a clue to human late-onset Alzheimer’s disease development"
Link:
Excerpts:
"Alzheimer’s disease (AD) is the leading cause of cognitive impairment and death among elderly people. Underlying pathology is accumulation of neurotoxic amyloid-β protein (“plaques”) and formation of TAU protein-rich neurofibrillary “Tangles” in the brain. ........"
"..........The study by University of Oklahoma Health Sciences Center researchers provides compelling evidence that Sgo1-/+ haploinsufficient mouse model displays AD-like brain pathology at an age that is equivalent to old age in humans. This unique mouse model developed in their study can be used to investigate spontaneous late-onset AD progression, as well as the genetic interactions between known AD-associated genes. It is hoped the new AD mouse model will advance our knowledge on the specific mechanisms of late-onset AD pathology and the development of better drugs for AD."
